Table 3. Pathophysiological contributions of K_2P channels to human diseases The table lists currently-known mechanisms of K_2P channels that lead to different pathological conditions. The general pathomechanisms include dysfunction in cell proliferation, volume homeostasis, barrier integrity, endocrine signaling, and electrical activities in both neurons and smooth muscle cells. MS: multiple sclerosis, RA: rheumatoid arthritis, SCD: sickle cell disease, FHEIG: facial dysmorphism, hypertrichosis, epilepsy, intellectual/developmental delay, and gingival overgrowth syndrome, HSCR: Hirschsprung disease, T2D: type 2 diabetes, IBS: irritable bowel syndrome. CNS: central nervous system, GI: gastrointestinal system